IVF with Over 30 Retrieved Eggs and Its Success Chances
- 1.1 How Does the Number of Eggs Retrieved in IVF Influence IVF Success Chances?
- 1.2 Step 1: Mature Eggs are Retrieved
- 1.3 Step 2: Eggs are Fertilized
- 1.4 Step 3: Embryos are Incubated
- 1.5 Step 4: Embryos are Checked for Chromosomal Abnormalities
- 1.6 Step 5: Embryos are Transferred for Implantation
- 1.7 Step 6: Pregnancy is Tested
- 1.8 IVF Success Chances with Over 30 Retrieved Eggs
- 1.8.1 Conclusion
The shoulder you consider IVF with over 30 retrieved eggs? Does it improve your IVF success chances? This article will help you find out.
This article briefly discusses the egg retrieval procedure, how many of a woman’s mature eggs are commonly retrieved for IVF, how the number of retrieved eggs influences IVF success chances, and do you really need over 30 retrieved eggs to have a successful IVF pregnancy.
How Many Eggs Are Commonly Retrieved in IVF?
Normally, most fertility clinics averagely retrieve 20 mature eggs for fertilization. Though it is not a static number. Depending on certain fertility factors, an IVF doctor can increase or decrease the number of mature eggs retrieved.
Retrieving more eggs does not always mean higher chances of IVF success. The number of eggs to be retrieved depends on fertility factors such as the woman’s age, presence of fertility disorders, history of genetic disorders, previous pregnancies and more. A younger woman; usually in her 20s or early 30s with high egg reserve and good egg quality have a greater chance of successfully conceiving with few retrieved eggs than a woman in her 40s who might require more mature eggs due to her diminishing egg reserve, low egg quality and increased risk of chromosomal abnormalities in the retrieved eggs.
How Does the Number of Eggs Retrieved in IVF Influence IVF Success Chances?
As mentioned above, about 20 mature eggs are usually retrieved for in-vitro fertilization and depending on the number of mature eggs retrieved; whether more or less, IVF success chances do differ.
Step 1: Mature Eggs are Retrieved
Mature eggs are retrieved or collected during the egg retrieval process where the woman is injected with certain fertility drugs such as clomiphene to stimulate the ovarian follicles and cause them to produce multiple mature eggs at a time. Normally, a woman produces only one mature egg per ovulation cycle which is only viable for fertilization for the next 24 to 48 hours. But with fertility drugs, IVF can make a woman produce several mature eggs which are further collected for fertilization by the intended father’s sperm in a laboratory.
But do you know? Not all produced eggs are mature and of high-quality to result in a healthy sustainable pregnancy. It can be a result of low egg reserve with aging or fertility disorders such as polycystic ovary syndrome (PCOS). Out of eggs produced through IVF ovarian stimulation, only the mature ones are retrieved.
Step 2: Eggs are Fertilized
After successful retrieval, retrieved mature eggs are fertilized by inseminating the intended father’s sperm in a lab. But, all retrieved eggs cannot fertilize successfully. On an average, only about 70 to 80% of the retrieved eggs could fertilize and this average can even lower if the couple has low egg or sperm quality issues.
Step 3: Embryos are Incubated
After successful fertilization, the fertilized eggs are now prepared for incubation in IVF incubators such as EmbryoScope. In this IVF stage, the fertilized eggs are kept in an incubator (a device that imitates the environment of a woman’s uterus) for 5 days where they reach the final stage of embryo development called a blastocyst. Throughout incubation, embryologists analyze embryo development to find out the embryos with the best potential to result in a healthy sustainable pregnancy. But on average, only 30 to 50% of the fertilized eggs could make it to day 5 (blastocyst).
Step 4: Embryos are Checked for Chromosomal Abnormalities
After embryos are successfully incubated and ready to be transferred back to the woman’s uterus for further development, they are checked for chromosomal abnormalities. Depending on certain fertility and genetic factors, developed embryos can have chromosomal abnormalities that might cause implantation failure.
Techniques like preimplantation genetic screening (PGS) and preimplantation genetic diagnosis (PGD) are used by embryologists to check embryos for chromosomal abnormalities and genetic disorders. On average, only 50% of the developed embryos are found chromosomally normal and ideal for implantation. This average can be lower due to certain fertility and genetic factors. In fact, a woman in her 40s only has 10 to 20% of her embryos chromosomally normal.
Step 5: Embryos are Transferred for Implantation
After developed embryos are checked for chromosomal normality, embryo transfer is the final IVF stage where the embryo is transferred back to the woman’s uterus to implant. Now, not every implanted embryo can successfully implant, with aging or due to certain reproductive problems, the chance of pregnancy per embryo transfer declines.
Step 6: Pregnancy is Tested
After successful embryo implantation, a pregnancy test is performed after 14 days of implantation where a blood test is taken to assess human chorionic gonadotropin (hCG) levels in the woman’s body. hCG levels in a non-pregnant woman is less than 5mIU/mL whereas having hCG levels higher than 200mIU/mL after 14 days of embryo transfer indicates a positive pregnancy.
IVF Success Chances with Over 30 Retrieved Eggs
As mentioned earlier, a higher number of retrieved eggs does not always mean higher IVF success chances. In cases when a woman is in her 20s or early 30s where her egg reserve, egg quality, and reproductive function are good, an IVF center in Gurgaon might not want to retrieve over 30 eggs for IVF. 20 or less mature eggs are a good number for retrieval.
But in cases when the woman’s age is 40 and above, a doctor might consider retrieving eggs as much as 30 or even more. It is because, with aging, women have a significant decline in their egg reserve, egg quality, and overall reproductive function which might cause a number of retrieved eggs to not make it to the embryo development (blastocyst) stage or have chromosomal abnormalities that may result in an implantation failure.
Always choose the right fertility clinic like Grace Fertility for your fertility-related treatments. It is foremost because a good fertility doctor will always ensure that you are getting the IVF treatment you require. Not all women may require IVF with over 30 retrieved eggs. Always consult with your gynecologist or obstetrician before you decide to go for a specific way to achieve pregnancy.